Low rates of adherence for tumor necrosis factor-α inhibitors in Crohn’s disease and rheumatoid arthritis: Results of a systematic review

Table 2 Determinants of adherence in Crohn's disease and rheumatoid arthritis

	Studies on Crohn's disease			Studies on rheumatoid arthritis
	Kane et al[7]	Billioud et al[17]	Kane et al[18]	Borah et al[19]	Li et al[21]
Female gender	OR < 1		OR < 1; P < 0.05		OR < 1
Increasing age		OR < 1			OR > 1
Immunomodulator use	OR > 1		OR < 1		OR > 1; P < 0.051
Prior biologic use	OR < 1; P < 0.05			OR > 1; P < 0.05
Increasing duration of therapy			OR < 1; P < 0.05
Increasing disease duration		OR > 1; P < 0.05

¹Significant at P < 0.05 for age 55-64 years (OR = 1.49).