Effect of amitriptyline on gastrointestinal function and brain-gut peptides: A double-blind trial

Table 1 Demographic and baseline characteristics of study in healthy volunteers

Variable	Group A (n = 14)	Group B (n = 14)	P value
Age (yr)	27.71 ± 8.56	32.5 ± 13.36	0.26
Sex (male)	7	7	1
BMI (kg/m2)	20.09 ± 1.41	20.21 ± 1.42	0.82
HAMD	2.36 ± 1.28	1.71 ± 1.20	0.29
HAMA	2.71 ± 1.73	3.36 ± 1.45	0.18
Cross-sectional area of the proximal stomach (cm2)
200 mL	17.13 ± 4.53	18.75 ± 2.30	0.08
400 mL	29.19 ± 6.24	30.76 ± 6.59	0.95
600 mL	40.92 ± 11.5	40.66 ± 7.28	0.35
800 mL	46.21 ± 12.16	46.46 ± 6.81	0.24
Difficulty in drinking water VAS
200 mL	0.79 ± 0.58	1.07 ± 0.62	0.23
400 mL	1.79 ± 0.58	1.86 ± 0.54	0.71
600 mL	3.21 ± 0.80	3.50 ± 0.65	0.31
800 mL	5.50 ± 0.76	5.43 ± 0.76	0.82
Gastric emptying
5 min	77.65% ± 6.5%	81.46% ± 5.81%	0.67
10 min	62.61% ± 9.85%	65.18% ± 6.77%	0.55
OCTT (min)	88.93% ± 19.03%	81.43% ± 20.14%	0.46
Plasma levels (pg/mL)
MTL	502.66 ± 127.52	440.85 ± 123.25	0.20
Ghrelin	460.06 ± 146.25	444.94 ± 202.43	0.82
NPY	888.88 ± 154.52	913.46 ± 139.32	0.66

Values are represented as mean ± SD. Symptom scores on 10-cm visual analogue scale. HAMD: Hamilton depression rating scale; HAMA: Hamilton anxiety rating scale; BMI: Body mass index; OCTT: Orocecal transit time; NPY: Neuropeptide Y; MTL: Motilin; VAS: Visual analogue scale.