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World J Gastroenterol. Jul 7, 2013; 19(25): 3931-3941
Published online Jul 7, 2013. doi: 10.3748/wjg.v19.i25.3931
Published online Jul 7, 2013. doi: 10.3748/wjg.v19.i25.3931
Figure 1 Interleukin-10 signalling pathway.
Interleukin-10 (IL-10) binds to the tetrameric receptor IL-10 receptor (IL-10R) complex, this activates Janus kinase 1 (JAK1) and tyrosine kinase 2 (Tyk2), which self-phosphorylate resulting in the binding and phosphorylation of signal transducer and activator of transcription 3 (STAT3). STAT3 dimerises and translocates to the nucleus, inducing target genes. TNF-α: Tumor necrosis factor-α.
- Citation: Marlow GJ, van Gent D, Ferguson LR. Why interleukin-10 supplementation does not work in Crohn’s disease patients. World J Gastroenterol 2013; 19(25): 3931-3941
- URL: https://www.wjgnet.com/1007-9327/full/v19/i25/3931.htm
- DOI: https://dx.doi.org/10.3748/wjg.v19.i25.3931