CYP1A1, GSTM1, GSTT1 and NQO1 polymorphisms and colorectal adenomas in Japanese men

doi:10.3748/wjg.v19.i25.4023

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 7, 2013; 19(25): 4023-4030
Published online Jul 7, 2013. doi: 10.3748/wjg.v19.i25.4023

Table 2 Associations between genetic polymorphisms and colorectal adenomas n (%)

Genotype	Cases	Controls	Crude	Adjusted³
			OR (95%CI)
CYP1A12A*
0¹	174 (38.2)	388 (36.9)	1.00 (referent)	1.00 (referent)
1	219 (48.1)	508 (48.3)	0.96 (0.76-1.22)	0.97 (0.76-1.24)
2	62 (13.6)	156 (14.8)	0.89 (0.63-1.25)	0.86 (0.60-1.23)
CYP1A12C*
0¹	281 (61.8)	611 (58.1)	1.00 (referent)	1.00 (referent)
1	152 (33.4)	389 (37.0)	0.85 (0.67-1.07)	0.81 (0.64-1.03)
2	22 (4.8)	52 (4.9)	0.92 (0.55-1.54)	0.94 (0.55-1.60)
GSTM1
Non-null	200 (44.0)	506 (48.1)	1.00 (referent)	1.00 (referent)
Null	255 (56.0)	546 (51.9)	1.18 (0.95-1.47)	1.19 (0.94-1.49)
GSTT1
Non-null	258 (56.7)	552 (52.5)	1.00 (referent)	1.00 (referent)
Null	197 (43.3)	500 (47.5)	0.84 (0.68-1.05)	0.87 (0.70-1.10)
GSTM1 + GSTT1
0²	118 (25.9)	273 (26.0)	1.00 (referent)	1.00 (referent)
1	222 (48.8)	512 (48.7)	1.00 (0.77-1.31)	1.04 (0.79-1.37)
2 (both null)	115 (25.3)	267 (25.4)	1.00 (0.73-1.35)	1.04 (0.76-1.42)
NQO1 C609T
CC	161 (35.4)	412 (39.2)	1.00 (referent)	1.00 (referent)
CT	220 (48.4)	489 (46.5)	1.15 (0.90-1.47)	1.18 (0.92-1.52)
TT	74 (16.3)	151 (14.4)	1.25 (0.90-1.75)	1.31 (0.93-1.84)

¹Number of variant alleles;

²Number of null genotypes;

³Adjusted for age, hospital, rank in the Self-Defense Forces, body mass index, cigarette smoking, alcohol use, leisure-time physical activity and parental history of colorectal cancer.

Citation: Hamachi T, Tajima O, Uezono K, Tabata S, Abe H, Ohnaka K, Kono S. CYP1A1, GSTM1, GSTT1 and NQO1 polymorphisms and colorectal adenomas in Japanese men. World J Gastroenterol 2013; 19(25): 4023-4030
URL: https://www.wjgnet.com/1007-9327/full/v19/i25/4023.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i25.4023