Bone-marrow mesenchymal stem cells reduce rat intestinal ischemia-reperfusion injury, ZO-1 downregulation and tight junction disruption via a TNF-α-regulated mechanism

Table 4 Serum levels of tumor necrosis factor-α and intestinal mucosal injury grade after intestinal ischemia/reperfusion

Group	TNF-α(pg/mL)					Chiu’s grade scores
	2 h	6 h	24 h	72 h	144 h	2 h	6 h	24 h	72 h	144 h
Saline + I/R injury group	243.27	290.41	210.51	186.58	132.55	19	28	18	14	10
	212.21	286.35	241.42	189.44	125.39	14	27	21	14	8
	221.76	283.66	203.19	174.82	137.45	17	30	17	13	10
	235.42	295.87	210.37	175.76	129.57	18	28	19	13	9
	229.54	345.78	226.96	189.26	145.57	18	29	20	14	12
	215.74	395.61	238.32	169.34	138.51	15	30	21	12	10
Spearman						0.947	0.931	0.961	0.971	0.956
P						0.004	0.011	0.002	0.001	0.003

The degree of relationship between tumor necrosis factor (TNF)-α and the Chiu risk score was evaluated by bivariate correlation. The results were statistically significant when P < 0.05, and was highly significant when P < 0.01. I/R: Ischemia/reperfusion.