Mechanisms of trichostatin A inhibiting AGS proliferation and identification of lysine-acetylated proteins

Figure 5 mRNA expression levels of p21, p53, Bax, Bcl-2, CDK2 and CyclinD1 in AGS cells exposed to 0. 25 μmol/L trichostatin A shown by real-time polymerase chain reaction. The mRNA expression levels of Bcl-2, CDK2 and CyclinD1 were decreased and the mRNA expression levels of p21, p53 and Bax were increased 12 h after AGS cells were exposed to 0.25 μmol/L trichostatin A. The mRNA expression levels of Bcl-2, CDK2 and CyclinD1 were further decreased and the mRNA expression levels of p21, p53 and Bax were further increased 24 h after exposure.