A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes

Table 1 Characteristics and fat infiltration of rats fed a choline-deficient diet or a high fat diet with or without Realsil or a normal choline-supplemented diet (controls)

Characteristics	Controls	CD	CD + Realsil	HFD	HFD + Realsil	Controls	HFD	HFD + Realsil
	day 30	day 30	day 30	day 30	day 30	day 60	day 60	day 30
Body weight (g)	305 ± 8	311 ± 12	304 ± 11	302 ± 10	308 ± 12	355 ± 11	364 ± 13	351 ± 12
Liver weight (g)	12.7 ± 0.5	19.7 ± 1.3a	16.7 ± 0.7a	15.7 ± 1.7a	13.1 ± 1.3	12.7 ± 0.5	18.8 ± 1.1a	15.1 ± 0.6ac
ALT (IU/L)	30 ± 8	92 ± 14a	68 ± 12ac	42 ± 10a	31 ± 7c	30 ± 8	69 ± 11a	52 ± 8ac
% area	3 ± 2	311 ± 12	304 ± 11	16 ± 4	8 ± 3	4 ± 1	20 ± 4	15 ± 3ac
No. of droplets	11 ± 5	19.7 ± 1.3a	16.7 ± 0.7a	570 ± 47a	356 ± 23	12 ± 6	389 ± 31a	519 ± 26ac
Mean droplet diameter	1.1 ± 0.3	9.2 ± 1.4a	6.8 ± 1.2ac	4.2 ± 1.0a	3.2 ± 0.7c	0.9 ± 0.5	4.4 ± 1.1a	3.4 ± 0.9ac

Data represent percentage of fat in the whole area, number of fat droplets and mean diameter of the droplets. Results are mean ± SD of n = 5 different slides per rat per group at each time point.

^aP < 0.05 vs control rats;

^cP < 0.05 vs choline-deficient diet (CD) or high fat diet (HFD) only. ALT: Alanine transaminase.