Dietary polyphenols and colorectal cancer risk: The Fukuoka colorectal cancer study

Table 3 Multivariate-adjusted odds ratio (95%CI) of colon and rectal cancers according to polyphenols intake

Nutrient	Quintile of intake					Ptrend
	Q1 (low)	Q2	Q3	Q4	Q5 (high)
Total polyphenols
Colon
Cases/controls	111/163	110/163	76/163	80/163	86/163
OR (95%CI)1	1 (reference)	0.90 (0.63, 1.29)	0.66 (0.45, 0.96)	0.73 (0.50, 1.07)	0.81 (0.55, 1.18)	0.13
Proximal colon
Cases/controls	40/163	45/163	34/163	38/163	31/163
OR (95%CI)1	1 (reference)	0.91 (0.55, 1.52)	0.78 (0.46, 1.33)	0.91 (0.53, 1.54)	0.79 (0.45, 1.38)	0.44
Distal colon
Cases/controls	70/163	64/163	42/163	42/163	54/163
OR (95%CI)1	1 (reference)	0.86 (0.56, 1.31)	0.57 (0.36, 0.91)	0.61 (0.38, 0.98)	0.79 (0.50, 1.23)	0.11
Rectum
Cases/controls	77/163	60/163	62/163	56/163	85/163
OR (95%CI)1	1 (reference)	0.73 (0.48, 1.10)	0.73 (0.48, 1.11)	0.70 (0.46, 1.07)	1.08 (0.72, 1.62)	0.74
Tea polyphenols
Colon
Cases/controls	64/163	92/163	103/163	98/163	106/163
OR (95%CI)1	1 (reference)	1.37 (0.91, 2.05)	1.50 (1.00, 2.23)	1.34 (0.89, 2.03)	1.42 (0.95, 2.14)	0.18
Proximal colon
Cases/controls	21/163	33/163	44/163	41/163	49/163
OR (95%CI)1	1 (reference)	1.38 (0.75, 2.54)	1.77 (0.98, 3.19)	1.42 (0.77, 2.61)	1.82 (1.01, 3.30)	0.08
Distal colon
Cases/controls	43/163	58/163	58/163	56/163	57/163
OR (95%CI)1	1 (reference)	1.36 (0.85, 2.19)	1.32 (0.82, 2.12)	1.26 (0.77, 2.06)	1.18 (0.72, 1.92)	0.74
Rectum
Cases/controls	62/163	57/163	80/163	56/163	85/163
OR (95%CI)1	1 (reference)	0.89 (0.57, 1.36)	1.25 (0.83, 1.88)	0.91 (0.59, 1.42)	1.27 (0.84, 1.93)	0.25
Coffee polyphenols
Colon
Cases/controls	128/163	103/163	82/163	75/163	75/163
OR (95%CI)1	1 (reference)	0.92 (0.64, 1.31)	0.75 (0.52, 1.08)	0.69 (0.47, 1.01)	0.68 (0.46, 1.00)	0.02
Proximal colon
Cases/controls	52/163	41/163	34/163	32/163	29/163
OR (95%CI)1	1 (reference)	0.89 (0.55, 1.44)	0.75 (0.45, 1.25)	0.76 (0.45, 1.27)	0.70 (0.41, 1.20)	0.15
Distal colon
Cases/controls	76/163	61/163	47/163	42/163	46/163
OR (95%CI)1	1 (reference)	0.89 (0.58, 1.35)	0.72 (0.46, 1.12)	0.62 (0.39, 0.98)	0.66 (0.42, 1.04)	0.02
Rectum
Cases/controls	90/163	62/163	48/163	53/163	87/163
OR (95%CI)1	1 (reference)	0.65 (0.44, 0.98)	0.50 (0.33, 0.77)	0.55 (0.36, 0.84)	0.93 (0.63, 1.37)	0.51

¹Adjusted for age, sex, residence area, parental history of colorectal cancer, smoking, alcohol drinking, body mass index 10 years before, type of job, leisure-time physical activity, calcium and n-3 polyunsaturated fatty acid. OR: Odds ratio.