Dietary polyphenols and colorectal cancer risk: The Fukuoka colorectal cancer study

Table 2 Association of dietary polyphenol intakes with colorectal cancer risk

Nutrient (unit)	Quintile of intake					Ptrend
	Q1 (low)	Q2	Q3	Q4	Q5 (high)
Total polyphenols
Median (mg/d)	534	812	1047	1335	2104
Cases/controls	190/163	170/163	142/163	138/163	176/163
OR (95%CI)1	1 (reference)	0.85 (0.62, 1.16)	0.72 (0.52, 0.98)	0.74 (0.54, 1.02)	0.95 (0.70, 1.31)	0.52
OR (95%CI)2	1 (reference)	0.85 (0.62, 1.16)	0.72 (0.52, 1.00)	0.74 (0.54, 1.03)	0.97 (0.70, 1.33)	0.59
Tea polyphenols
Median (mg/d)	65	224	397	475	853
Cases/controls	128/163	151/163	184/163	157/163	196/163
OR (95%CI)1	1 (reference)	1.14 (0.82, 1.58)	1.37 (0.99, 1.89)	1.13 (0.81, 1.58)	1.37 (0.99, 1.90)	0.09
OR (95%CI)2	1 (reference)	1.13 (0.81, 1.57)	1.36 (0.98, 1.88)	1.16 (0.83, 1.62)	1.38 (0.99, 1.92)	0.08
Coffee polyphenols
Median (mg/d)	0	82	260	541	1287
Cases/controls	220/163	167/163	133/163	129/163	167/163
OR (95%CI)1	1 (reference)	0.80 (0.59, 1.08)	0.65 (0.48, 0.90)	0.64 (0.46, 0.87)	0.83 (0.60, 1.13)	0.09
OR (95%CI)2	1 (reference)	0.81 (0.60, 1.10)	0.65 (0.47, 0.89)	0.65 (0.46, 0.89)	0.82 (0.60, 1.12)	0.07
Polyphenols other than coffee
Median (mg/d)	280	466	631	790	1104
Cases/controls	131/163	158/163	181/163	166/163	180/163
OR (95%CI)1	1 (reference)	1.17 (0.85, 1.63)	1.29 (0.93, 1.79)	1.13 (0.81, 1.58)	1.23 (0.88, 1.72)	0.35
OR (95%CI)2	1 (reference)	1.19 (0.86, 1.66)	1.31 (0.94, 1.82)	1.20 (0.85, 1.69)	1.31 (0.93, 1.84)	0.19

¹Adjusted for age, sex, residence area, parental history of colorectal cancer, smoking, alcohol drinking, body mass index 10 years before, type of job and leisure-time physical activity;

²Further adjusted for calcium and n-3 polyunsaturated fatty acids. OR: Odds ratio.