Meta-Analysis
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 28, 2013; 19(16): 2560-2568
Published online Apr 28, 2013. doi: 10.3748/wjg.v19.i16.2560
Table 1 Characteristics of observational studies on acid suppressive drugs and gastric cancer
Ref.CountryDesignStudy periodRange of age (yr)PopulationDrugsAdjusted OR or RR (95%CI)Study quality1Adjustment for covariates
La Vecchiaet al[23]ItalyCC1985-198927-74563 cases and 1501 controlsCimetidine, Ranitidine1.80 (1.20 -2.70)5Age, sex, education, smoking, alcohol, coffee
Johnson et al[24]United StatesCC1988-1992NA113 cases and 452 matched controlsCimetidine, Ranitidine2.00 (1.00 -3.90)5Age, sex, first pharmacy use
Møller et al[25]DenmarkPCC1977-1990NA134 cases among 16739Cimetidine2.30 (1.60-3.10)6Age, sex, diagnosis, method of diagnosis
Schumacher et al[26]United StatesCC1981-198717-9499 cases and 365 controlsCimetidine2.30 (0.80 -6.90)6Age, sex, date of first pharmacy use
Chow et al[27]United StatesMCC1986-1992NA196 cases and 200 controlsCimetidine, Ranitidine, Famotidine, Nizatidine0.60 (0.30-1.30)6Race, smoking, BMI, number of composite conditions2
Farrow et al[52]United StatesPBCC1993-199530-79293 esophageal adenoca, 221 esophageal SCC, 261 gastric cardia adenoca, 368 non-cardia gastric adenoca and 695 controlsCimetidine, Ranitidine, Famotidine, Nizatidine1.00 (0.60-1.90)7Age, sex, study center, smoking, BMI, history of gastric or duodenal ulcer, GERD symptom frequency, alcohol
Suleiman et al[53]United KingdomNCC1990-1992NA231 cases among 9876 controlsCimetidine, Ranitidine2.56 (0.17-38.09)7Age, sex, MI, antacid, steroid, smoking, alcohol, social class, height, weight
García Rodríguez et al[54]United KingdomNCC1994-200140-84287 esophageal adenoca, 195 gastric cardiac adenoca, 327 gastric non-cardia adenoca and 10000 controlsH2RAs, PPIs1.24 (0.88-1.75)8Age, sex, calendar year, smoking, alcohol, BMI, UGI disorder, hiatal hernia, GU, DU, dyspepsia
Tamim et al[55]CanadaNCC1995-2003NA1589 cases and 12991 controlsH2RAs, PPIs1.37 (1.22-1.53)8Age, sex number of prescriptions to any drug, total length of hospitalizations and number of visit to GPs, specialist, emergency rooms
Duan et al[56]United StatesPBCC1992-1997NA220 esophageal adenoca, 277 gastric cardiac adenoca, 441 distal gastric adenoca and 1356 controlsH2RAs, PPIs1.15 (0.58 -2.29)7Age, sex, race, birthplace, education, smoking, BMI, history of UGI symptom
Poulsen et al[57]DenmarkPCC1990-2003NA161 cases among users of 18790 PPIs or 17478 H2RAsOmeprazole, Lanzoprazole, Esomeprazole, Pantoprazole, Rabeprazole, Cimetidine, Ranitidine, Nizatidine, Famotidine1.30 (0.70-2.30)8Age, sex, calendar period, history of H.pylori, gastroscopy year, COPD, alcohol, NSAID