Genetic association of interleukin-6 polymorphism (-174 G/C) with chronic liver diseases and hepatocellular carcinoma

Table 2 Studies examining the role of interleukin-6 polymorphism (-174 G/C) in alcoholic and autoimmune liver diseases

Ref.	Country	Ethnicity	Cases	Controls	Genotyping method	Association
Carulli et al[33]	Italy	Caucasian	79	114	PCR-RFLP	Positive significant (NAFLD)
Fernández-Real et al[34]	Spain	Caucasian	32	-	PCR-RFLP	Positive significant (diabetes and lipid abnormalities) (G allele)
Marcos et al[48]	Spain	Caucasian	258	101	TaqMan genotyping	NS (alcoholic liver disease)
Fan et al[53]	China	Asian	77	-	PCR-RFLP	Positive significant (PBC)

PCR-RFLP: Polymerase chain reaction - restriction fragment length polymorphism; NAFLD: Non-alcoholic fatty liver disease; PBC: Primary biliary cirrhosis.