Elevated serum levels of human relaxin-2 in patients with esophageal squamous cell carcinoma

Table 3 Univariate and multivariate survival analysis in patients with esophageal squamous cell carcinoma

Characteristic	Univariate analysis			Multivariate analysis
	HR	95%CI	P value1	HR	95%CI	P value1
Age (yr)
< 65 vs≥ 65	1.321	0.864-1.743	0.185	1.268	0.747-1.826	0.174
Gender
Male vs female	0.942	0.621-1.563	0.342	0.852	0.732-1.472	0.296
Lymph node involvement
Yes vs no	2.136	1.142-2.687	< 0.001	2.830	1.384-2.982	0.001
Distant metastasis
Yes vs no	3.784	2.543-5.894	< 0.001	3.549	1.302-3.108	0.001
pTNM
I-II vs III-IV	3.120	2.148-5.143	< 0.001	1.632	1.130-2.740	0.028
Lymphovascular invasion
Yes vs no	1.121	0.765-1.574	0.129	1.290	0.862-1.420	0.172
H2 RLN level
< 0.462 ng/mL vs≥ 0.462 ng/mL	2.469	1.362-2.836	0.015	2.530	1.424-2.732	0.003

¹Cox hazard regression model. HR: Hazard ratio; TNM: Tumor-node-metastasis; H2 RLN: Human relaxin 2.