Effects of Lizhong Tang on cultured mouse small intestine interstitial cells of Cajal

Figure 3 Effects of an external Ca²⁺-free solution, thapsigargin (an inhibitor of Ca ²⁺-ATPase in the endoplasmic reticulum), or U-73122 (an active phospholipase C inhibitor) on Lizhong Tang-induced pacemaker potentials in cultured interstitial cells of Cajal. A: External Ca²⁺-free solution abolished the generation of pacemaker potentials, but failed to block Lizhong Tang-induced (30 mg/mL) membrane depolarization; B: Thapsigargin (5 μmol/L) abolished the generation of pacemaker potentials, and blocked Lizhong Tang-induced (30 mg/mL) membrane depolarization; C: The responses to Lizhong Tang in external Ca²⁺-free solution in the presence of thapsigargin are summarized. Bars represent mean ± SE. ^bP < 0.01 vs control group. CTRL: Control.