Effects of Lizhong Tang on cultured mouse small intestine interstitial cells of Cajal

Figure 2 Effects of flufenamic acid (a nonselective cation channel blocker) or niflumic acid (a Cl^- channel blocker) on Lizhong Tang-induced pacemaker potentials in cultured interstitial cells of Cajal from murine small intestines. A: The application of flufenamic acid (5 μmol/L) abolished the generation of pacemaker potentials, and in the presence of flufenamic acid, Lizhong Tang (30 mg/mL) did not cause membrane depolarization; B: In contrast, although niflumic acid (5 μmol/L) abolished the generation of pacemaker potentials, it did not block Lizhong Tang-induced (30 mg/mL) membrane depolarization; C: The responses to Lizhong Tang in the presence of flufenamic acid or niflumic acid are summarized. Bars represent mean ± SE. ^bP < 0.01 vs control group. CTRL: Control.