Extended antimicrobial prophylaxis after gastric cancer surgery: A systematic review and meta-analysis

Table 2 Secondary characteristics of the randomized controlled trails included in the meta-analysis

Ref.	Participants	n	Interventions	Complications
Schardey et al[7]	205 patients August 1991-March 1994 Germany, multi-centre, ≥ 18 yr, total gastrectomy	102 vs 103	Polymyxin B 0.1 g, tobramycin 0.08 g, vancomycin 0.125 g and amphotericin B 0.5 g four times per day orally from the day before operation until 7th postoperative day plus perioperative intravenous prophylaxis: cefotaxime 2 × 2 g vs placebo plus perioperative intravenous prophylaxis: cefotaxime 2 × 2 g	Infections: Pulmonary, urinary tract; abscess; Insufficiency: Pancreatic, esophagointestinal; miscellaneous; pancreatic fistula
Farran et al[8]	49 patients January 2000-March 2005, single centre, ≥ 18 yr, total gastrectomy	22 vs 27	20 mL oral suspension of erythromycin 0.5 g + gentamicine 0.08 g + nystatin sulfate 0.1 g vs 20 mL placebo solution. Both groups started treatment 12 h before surgery and continued until the 5th postoperative day	Dehiscence; sepsis; abscess;pulmonary infection;pulmonary distress syndrome
Imamura et al[9]	355 patients June 2005-December 2007, Japan, multi-centre, ≥ 35 yr, distal gastrectomy	179 vs 176	Intraoperative administration plus cefazolin 1 g once after closure and twice daily for 2 postoperative days vs intraoperative administration: cefazolin 1 g before surgical incision and every 3 h as intraoperative supplements	Anastomotic leakage; remote infections; surgical site infections
Mohri et al[10]	486 patients May 2001-December 2004 Japan, single-centre, ≥ 20 yr, elective gastrectomy	243 vs 243	Intraoperative schedule: cefazolin 1 g or ampicillin-sulbactam 1.5 g by intravenous infusion > 15 min and an additional dose was administrated if operation > 3 h vs intraoperative schedule plus further treatment at 12-h intervals, a total of 7 doses	Surgical site infection: incision or organ or space; abscess