Evaluation of the relationship between dietary factors, CagA-positive Helicobacter pylori infection, and RUNX3 promoter hypermethylation in gastric cancer tissue

Table 4 Associations between micronutrients and mineral salts intake and RUNX3 methylation risk, according to CagA status

	Total subjects		CagA(-) or H. pylori (-)		CagA(+)
	Methylated/unmethylated	OR (95%CI)1	Methylated/unmethylated	OR (95%CI)1	Methylated/unmethylated	OR (95%CI)1
Protein
Low	54/39	1.0	35/26	1.0	19/13	1.0
High	52/39	0.90 (0.50-1.64)	37/27	0.95 (0.46-1.95)	15/12	0.86 (0.29-2.57)
Fat
Low	60/39	1.0	38/23	1.0	22/16	1.0
High	46/39	0.74 (0.21-1.35)	34/30	0.66 (0.32-1.36)	12/9	0.98 (0.30-3.25)
Carbohydrate
Low	71/39	1.0	53/28	1.0	18/11	1.0
High	35/39	0.48 (0.25-0.91)3	19/25	0.41 (0.19-0.90)3	16/14	0.53 (0.15-1.91)
Vitamin A
Low	57/39	1.0	36/27	1.0	21/12	1.0
High	49/39	0.73 (0.40-1.35)	36/26	0.88 (0.42-1.86)	13/13	0.51 (0.17-1.56)
Vitamin B1
Low	65/40	1.0	48/24	1.0	17/15	1.0
High	41/38	0.67 (0.36-1.22)	24/29	0.42 (0.20-0.89)23	17/10	2.04 (0.63-6.62)2
Vitamin B2
Lo	56/39	1.0	37/25	1.0	19/14	1.0
High	50/39	0.81 (0.44-1.48)	35/28	0.77 (0.37-1.62)	15/11	0.97 (0.33-2.85)
Vitamin C
Low	66/39	1.0	50/31	1.0	16/8	1.0
High	40/39	0.56 (0.30-1.04)	22/22	0.59 (0.27-1.29)	18/17	0.38 (0.11-1.28)
Vitamin E
Low	73/39	1.0	54/24	1.0	19/15	1.0
High	33/39	0.47 (0.26-0.88)3	18/29	0.29 (0.13-0.62)23	15/10	1.30 (0.42-4.05)2

¹Adjusted for age, sex, total energy intake;

²Odds ratio (OR) was significantly different according to CagA status in a homogeneity test;

³P value < 0.05 statistically significant difference.