Heme status affects human hepatic messenger RNA and microRNA expression

Table 3 Summary of analysis with ingenuity pathway analytical tools

	6 h		24 h
Name	P value	No. molecules	P value	No. molecules
Hepatotoxicity
Liver proliferation	6.71 × 10-4 - 6.26 ×10-1	12	4.24× 10-3 - 1.63× 10-1	36
Liver necrosis/cell death	2.08 × 10-3 - 3.77 × 10-1	15	-	-
Liver damage	3.31 × 10-3 - 1.25 × 10-1	12	-	-
Liver hemorrhaging	7.28 × 10-3 - 7.28 × 10-3	2	-	-
Hepatocellular peroxisome proliferation	3.57 × 10-2 - 3.57 × 10-2	1	-	-
Liver cholestasis	-	-	1.11 × 10-5 - 6.55 × 10-1	32
Hepatocellular carcinoma	-	-	2.46 × 10-4 -2.46 × 10-4	54
Liver steatosis	-	-	2.59 × 10-3 - 1.00 × 10-0	34
Liver fibrosis	-	-	1.51 × 10-2 - 4.43 × 10-1	19
Nephrotoxicity
Renal necrosis/cell death	7.22 × 10-5 - 4.21 × 10-1	25	7.44 × 10-7 - 1.00E × 10-0	79
Kidney failure	1.27 × 10-3 - 2.24 × 10-1	10	2.64 × 10-2 - 6.55 × 10-1	26
Renal enlargement	1.27 × 10-3 - 1.03 × 10-1	2	2.64 × 10-2 - 4.13 × 10-1	2
Renal damage	3.09 × 10-2 - 5.83 × 10-1	4
Glomerular	3.57 × 10-2 - 5.17 × 10-1	2
Renal tubule injury			4.27 × 10-5 - 1.63 × 10-1	30
Renal proliferation			2.17 × 10-3 - 4.83 × 10-1	24