Effects of endoscopic sphincterotomy on biliary epithelium: A case-control study

Figure 1 Brush cytology samples. A: This is a sample that was evaluated as negative for malignancy. Note the smooth nuclear shape, the low nuclear/cytoplasmic ratio and the absence of nucleoli (Papanicolaou stain, x 400); B: This is a sample that was classified as atypical-indeterminate. Note the moderate nuclear/cytoplasmic ratio, the granular chromatin pattern with mild clumping and the presence of 1 or 2 small but distinct nucleoli (Papanicolaou stain, x 400); C: This is a p53-positive sample from the first group. There are at least five cells with strong nuclear staining (x 400). (Analysis of photos was performed with ACDSee Pro).