Routine blood tests to predict liver fibrosis in chronic hepatitis C

Table 6 Diagnostic accuracy of simple fibrosis prediction tests for significant and extensive fibrosis

Score	Cut-off value	(%)	Significant fibrosis (F2, F3 and F4)				Extensive fibrosis (F3 and F4)
			Sen	Spe	PPV	NPV	Sen	Spe	PPV	NPV
FibroQ	> 0.6	94.9	96.4	12.2	84.0	41.7	97.3	7.14	48.0	75.0
	> 1.2	79.7	85.7	48.8	88.9	41.7	90.1	29.4	52.9	77.1
	> 1.4	74.3	80.1	53.7	89.2	36.1	86.5	36.5	54.5	75.4
	> 1.6	70.0	77.6	65.9	91.6	38.0	85.6	43.7	57.2	77.5
	> 1.8	66.2	74.0	70.7	92.4	36.3	83.8	49.2	59.2	77.5
	> 2.0	60.8	69.4	80.5	94.4	35.5	82.0	57.9	63.2	78.5
	> 2.6	44.3	51.0	87.8	95.2	27.3	64.9	73.8	68.6	70.5
AAR	> 0.4	97.0	95.4	12.2	83.9	35.7	96.4	7.1	47.8	69.2
	> 0.6	61.2	67.9	70.7	91.7	31.5	77.5	53.2	59.3	72.8
	> 0.8	28.7	31.6	85.4	91.2	20.7	36.9	78.6	60.3	58.6
	> 1.0	6.8	8.16	100	100	18.5	10.8	96.8	75.0	55.2
APRI	> 0.5	95.8	96.9	9.7	83.7	40.0	99.1	7.1	48.5	90.0
	> 1	72.6	75.5	41.5	86.0	26.2	87.4	40.5	56.4	78.5
	> 1.5	54.0	56.6	58.5	86.7	22.0	69.4	59.5	60.2	68.8
	> 2	39.7	45.4	87.8	94.7	25.2	55.0	73.8	64.9	65.0
CDS	> 5	88.6	88.8	12.2	82.9	18.5	92.8	15.1	49.0	70.4
	> 6	63.7	66.3	48.8	86.1	23.3	73.9	45.2	54.3	66.3
	> 7	29.1	30.6	78.0	87.0	19.0	34.2	75.4	55.1	56.5
	> 8	8.9	9.7	95.1	90.5	18.1	12.6	94.4	66.7	55.1
API	> 4	75.9	81.6	51.2	88.9	36.8	87.4	34.1	53.9	75.4
	> 5	67.1	73.5	63.4	90.6	33.3	82.0	46.0	57.2	74.4
	> 6	57.4	63.3	70.7	91.2	28.7	74.8	57.9	61.0	72.3
	> 7	39.7	46.4	92.7	96.8	26.6	56.8	75.4	67.0	66.4
Pohl score	Positive	3.8	4.59	100	100	18.0	7.2	99.2	88.9	54.8
FIB-4	> 1.45	75.5	81.6	53.7	89.4	37.9	87.4	34.9	54.2	75.9
	> 2	62.0	69.4	73.2	92.5	33.3	81.1	54.8	61.2	76.7
	> 2.5	53.6	61.2	82.9	94.5	30.9	74.8	65.1	65.4	74.5
	> 3	46.0	52.6	85.4	94.5	27.3	66.7	72.2	67.9	71.1
	> 3.25	40.9	47.4	90.2	95.9	26.4	61.3	77.0	70.1	69.3
Lok’s model	> 0.2	74.7	81.6	58.5	90.4	40.4	88.3	37.3	55.4	78.3
	> 0.4	35.0	40.8	92.7	96.4	24.7	51.4	79.4	68.7	64.9
	> 0.5	24.1	28.6	97.6	98.2	22.2	37.8	88.1	73.7	61.7

AAR: AST/ALT ratio; APRI: AST-to-platelet ratio index; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; API: Age-platelet index; CDS: Cirrhosis discriminant score; Sen: Sensitivity; Spe: Specificity; PPV: Positive predictive value; NPV: Negative predictive value.