A pharmacodynamic model of portal hypertension in isolated perfused rat liver

Figure 4 Acetylcholine reduces portal pressure (mean ± SE, n_i = 4). The dose-effect relationship between Acetylcholine and portal vein relaxation in isolated portal perfused rat livers without chronic hepatitis, where rats were administered 3 mL/kg olive oil subcutaneously twice per week for 84 d (control rats) (d₀). Rats with chronic hepatitis at three stages, hepatic degeneration (d₂₈), fibrosis (d₅₆) and cirrhosis (d₈₄), were administered 3 mL/kg 40% (v/v) CCl₄ in olive oil subcutaneously twice per week for 28 d, 56 d and 84 d, respectively. Ach: Acetylcholine.