Single nucleotide polymorphisms in the CDH17 gene of colorectal carcinoma

Table 3 The correlation between the genotype of CDH17 gene c.2216A>C and clinicopathologic parameters in colorectal carcinomas n (%)

Clinicopathologic parameters	n	Genotype CDH17 c.2216A>G			χ2	P value
		A/A	A/C	C/C
Gender
Male	47	20 (42.6)	5 (10.6)	22 (46.8)	3.656	0.161
Female	46	11 (23.9)	7 (15.2)	28 (60.9)
Age (yr)
< 50	29	6 (20.7)	5 (17.2)	18 (62.1)	3.176	0.204
≥ 50	64	25 (39.1)	7 (10.9)	32 (50.0)
Tumor location
Colon	32	10 (31.3)	6 (18.8)	16 (50.0)	1.485	0.476
Rectum	61	21 (34.4)	6 (9.8)	34 (55.7)
Tumor size (cm)
< 5	68	25 (36.8)	5 (7.4)	38 (55.9)	7.144	0.0283
≥ 5	25	6 (24.0)	7 (28.0)	12 (48.0)
Macroscopic appearance
Protrude type	31	11 (35.5)	4 (12.9)	16 (51.6)	1.025	0.9061
Ulcer type	46	16 (34.8)	5 (10.9)	25 (54.3)
Infiltrating type	16	4 (25.0)	3 (18.8)	9 (56.3)
Colloid type	0	0 (0.0)	0 (0.0)	0 (0.0)
Histologic type
Adenocarcinoma	71	23 (32.4)	10 (14.1)	38 (53.5)	1.684	0.7941
Adenocarcinoma and mucinous carcinoma	9	4 (44.4)	0 (0.0)	5 (55.6)
Mucinous carcinoma	13	4 (30.8)	2 (15.4)	7 (53.8)
Undifferentiated carcinoma	0	0 (0.0)	0 (0.0)	0 (0.0)
Adenosquamous carcinoma	0	0 (0.0)	0 (0.0)	0 (0.0)
Squamous cell carcinoma	0	0 (0.0)	0 (0.0)	0 (0.0)
Invasion depth
Submucosa	2	2 (100.0)	0 (0.0)	0 (0.0)	1.610	0.4472
Muscular layer	34	12 (35.3)	4 (11.8)	18 (52.9)
Serous coat	48	14 (29.2)	5 (10.4)	29 (60.4)
Other organs	9	3 (33.3)	3 (33.3)	3 (33.3)
Differentiation degree
Well-differentiated	4	0 (0.0)	0 (0.0)	4 (100.0)	0.090	0.9562
Moderately-differentiated	63	24 (38.1)	9 (14.3)	30 (47.6)
Poorly-differentiated	26	7 (26.9)	3 (11.5)	16 (61.5)
Lymph node metastasis
No	59	25 (42.4)	10 (16.9)	24 (40.7)	11.143	0.0043
Yes	34	6 (17.6)	2 (5.9)	26 (76.5)
TNM grade
I	26	12 (46.2)	4 (15.4)	10 (38.5)	6.710	0.03523
II	31	12 (38.7)	5 (16.1)	14 (45.2)
III	33	6 (18.2)	2 (6.1)	25 (75.8)
IV	3	1 (33.3)	1 (33.3)	1 (33.3)
Hematogenous metastasis
No	90	30 (33.3)	11 (12.2)	49 (54.4)	1.243	0.5371
Yes	3	1 (33.3)	1 (33.3)	1 (33.3)
Recurrence
No	91	29 (31.9)	12 (13.2)	50 (54.9)	4.088	0.1301
Yes	2	2 (100.0)	0 (0.0)	0 (0.0)

¹The Fisher’s Exact Test;

²The Kruskal-Wallis Test;

³Statistically significant.