Single nucleotide polymorphisms in the CDH17 gene of colorectal carcinoma

doi:10.3748/wjg.v18.i48.7251

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 18, Issue 48

This Article

(0)

(8)

(5144)

(9)

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Original Article

World J Gastroenterol. Dec 28, 2012; 18(48): 7251-7261
Published online Dec 28, 2012. doi: 10.3748/wjg.v18.i48.7251

Table 2 The correlation between the genotype of CDH17 gene c.343A>G and clinicopathologic parameters in colorectal carcinomas n (%)

Clinicopathologic parameters	n	*Genotype CDH17* c.343A>G**			χ²	P value
Clinicopathologic parameters	n	A/A	A/G	G/G	χ²	P value
Gender
Male	47	10 (21.3)	25 (53.2)	12 (25.5)	2.236	0.327
Female	46	16 (34.8)	19 (41.3)	11 (23.9)	2.236	0.327
Age (yr)
< 50	29	10 (34.5)	15 (51.7)	4 (13.8)	2.854	0.240
≥ 50	64	16 (25)	29 (45.3)	19 (29.7)	2.854	0.240
Tumor location
Colon	32	8 (25.0)	16 (50.0)	8 (25.0)	0.229	0.892
Rectum	61	18 (29.5)	28 (45.9)	15 (24.6)	0.229	0.892
Tumor size (cm)
< 5	68	18 (26.5)	34 (50.0)	16 (23.5)	0.734	0.693
≥ 5	25	8 (32.0)	10 (40.0)	7 (28.0)	0.734	0.693
Macroscopic appearance
Protrude type	31	8 (25.8)	17 (54.8)	6 (19.4)	1.948	0.745¹
Ulcer type	46	12 (26.1)	21 (45.7)	13 (28.3)
Infiltrating type	16	6 (37.5)	6 (37.5)	4 (25.0)
Colloid type	0	0 (0.0)	0 (0.0)	0 (0.0)
Histologic type
Adenocarcinoma	71	18 (25.4)	34 (47.9)	19 (26.8)	2.179	0.703¹
Adenocarcinoma and mucinous carcinoma	9	4 (44.4)	3 (33.3)	2 (22.2)
Mucinous carcinoma	13	4 (30.8)	7 (53.8)	2 (15.4)
Undifferentiated carcinoma	0	0 (0.0)	0 (0.0)	0 (0.0)
Adenosquamous carcinoma	0	0 (0.0)	0 (0.0)	0 (0.0)
Squamous cell carcinoma	0	0 (0.0)	0 (0.0)	0 (0.0)
Invasion depth
Submucosa	2	0 (0.0)	2 (100.0)	0 (0.0)	0.696	0.706²
Muscular layer	34	12 (35.3)	15 (44.1)	7 (20.6)
Serous coat	48	12 (25)	21 (43.8)	15 (31.3)
Other organs	9	2 (22.2)	6 (66.7)	1 (11.1)
Differentiation degree
Well-differentiated	4	0 (0.0)	2 (50.0)	2 (50.0)	2.212	0.331²
Moderately-differentiated	63	17 (27.0)	33 (52.4)	13 (20.6)
Poorly-differentiated	26	9 (34.6)	9 (34.6)	8 (30.8)
Lymph node metastasis
No	59	16 (27.1)	35 (59.3)	8 (13.6)	13.105	0.001³
Yes	34	10 (29.4)	9 (26.5)	15 (44.1)	13.105	0.001³
TNM grade
I	26	8 (30.8)	16 (61.5)	2 (7.7)	10.344	0.006²³
II	31	7 (22.6)	18 (58.1)	6 (19.4)
III	33	9 (27.3)	9 (27.3)	15 (45.5)
IV	3	2 (66.7)	1 (33.3)	0 (0.0)
Hematogenous metastasis
No	90	24 (26.7)	43 (47.8)	23 (25.6)	2.556	0.279¹
Yes	3	2 (66.7)	1 (33.3)	0 (0.0)	2.556	0.279¹
Recurrence
No	91	24 (26.4)	44 (48.4)	23 (25.3)	5.267	0.072¹
Yes	2	2 (100.0)	0 (0.0)	0 (0.0)	5.267	0.072¹

¹The Fisher’s Exact Test;

²The Kruskal-Wallis Test;

³Statistically significant.

Full Size Table

Citation: Chen RY, Cao JJ, Chen J, Yang JP, Liu XB, Zhao GQ, Zhang YF. Single nucleotide polymorphisms in the CDH17 gene of colorectal carcinoma. World J Gastroenterol 2012; 18(48): 7251-7261
URL: https://www.wjgnet.com/1007-9327/full/v18/i48/7251.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i48.7251

Chen RY, Cao JJ, Chen J, Yang JP, Liu XB, Zhao GQ, Zhang YF. Single nucleotide polymorphisms in the CDH17 gene of colorectal carcinoma. World J Gastroenterol 2012; 18(48): 7251-7261 [PMID: 23326130 DOI: 10.3748/wjg.v18.i48.7251]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.