Glycogenotic hepatocellular carcinoma with glycogen-ground-glass hepatocytes: A heuristically highly relevant phenotype

Figure 2 Portion of a glycogenotic acidophilic hepatocyte (corresponding to glycogen-ground-glass hepatocyte) induced in rat liver by N-nitrosomorpholine. Note abundant α- and β-glycogen particles (G) in close spatial relationship with large network complexes of proliferated smooth endoplasmic reticulum (SER). Rough endoplasmic reticulum (RER), mitochondria (M), peroxisomes (P), and nucleus (N). Inset: Group of acidophilic hepatocytes as seen under the light microscope. Transmission electron microscopy, lead citrate. Bar: 1 μm.