PNPLA3, the triacylglycerol synthesis/hydrolysis/storage dilemma, and nonalcoholic fatty liver disease

Figure 2 Protein network around patatin-like phospholipase domain containing 3 by the Search Tool for the Retrieval of Interacting Genes/Proteins resource (http://string-db.org/). The interactions include direct (physical) and indirect (functional) associations; they are derived from four sources: Genomic Context, High-throughput Experiments, Conserved-Coexpression and Previous Knowledge. PNPLA3: Patatin-like phospholipase domain containing 3; LIPF: Lipase, gastric; SNX4: Sorting nexin 4; AGPAT9: 1-acylglycerol-3-phosphate O-acyltransferase 9; MGLL: Monoglyceride lipase; GPAM: Glycerol-3-phosphate acyltransferase, mitochondrial; AGPAT3: 1-acylglycerol-3-phosphate O-acyltransferase 3; LIPC: Lipase, hepatic; MBOAT2: Membrane-bound O-acyltransferase domain containing 2; LCLAT1: Lysocardiolipin acyltransferase 1; AGPAT4: 1-acylglycerol-3-phosphate O-acyltransferase 4; LPCAT3: Lysophosphatidylcholine acyltransferase 3; AGK: Acylglycerol kinase; PNLIPRP1: Pancreatic lipase-related protein 1, GPAT2: Glycerol-3-phosphate acyltransferase 2, mitochondrial; PNLIP: Pancreatic lipase; PDLIM1: PDZ and LIM domain 1; AGPAT2: 1-acylglycerol-3-phosphate O-acyltransferase 2; CEL: Carboxyl ester lipase; EIF2C4: Eukaryotic translation initiation factor 2C, 4; HCK: Hemopoietic cell kinase; AGPAT6: 1-acylglycerol-3-phosphate O-acyltransferase 6; ENSG00000228892: 1-acyl-sn-glycerol-3-phosphate acyltransferase.