Current progress in the treatment of chronic hepatitis C

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Nov 14, 2012 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 14, 2012; 18(42): 6060-6069
Published online Nov 14, 2012. doi: 10.3748/wjg.v18.i42.6060

Table 1 New agents against hepatitis C virus currently evaluated in phase II or III trials

Drug	Company
NS3/4A protease inhibitors
First generation, linear
Boceprevir (Approved)	MERCK
Telaprevir (Approved)	JANSSEN
Narlaprevir	MERCK
First generation, macrocyclic
BI201335	BOEHRINGER Ingelheim
TMC435	TIBOTEC/JANSSEN
Danoprevir	ROCHE
Vaniprevir	MERCK
Asunaprevir	BRISTOL-MYERS SQUIBB
ABT-450	ABBOTT
GS-9451	GILEAD
GS-9256	GILEAD
ACH-1625	ACHILLION
Second generation, macrocyclic
MK-5172	MERCK
Nucleos(t)ide analogue inhibitors of HCV polymerase
PSI/GS-7977	PHARMASSET/GILEAD
Mericitabine	ROCHE
IDX-184	IDENIX
Non-nucleoside analogue inhibitors of HCV polymerase
Tegobuvir	GILEAD
Filibuvir	PFIZER
ANA-598/Setrobuvir	ANADYS/ROCHE
BI207127	BOEHRINGER Ingelheim
ABT-333	ABBOTT
ABT-072	ABBOTT
VX-222	VERTEX
NS5A inhibitors
Daclatasvir	BRISTOL-MYERS SQUIBB
GS-5885	GILEAD
GSK2336805	GSK
Cyclophilin inhibitors
Alisporivir¹	NOVARTIS
SCY-635	Scynexis

¹On hold by the United States Food and Drug Administration because of toxicity (pancreatitis cases with one death). HCV: Hepatitis C virus.

Citation: Alexopoulou A, Papatheodoridis GV. Current progress in the treatment of chronic hepatitis C. World J Gastroenterol 2012; 18(42): 6060-6069
URL: https://www.wjgnet.com/1007-9327/full/v18/i42/6060.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i42.6060