Multimodality approach for locally advanced esophageal cancer

Table 3 Randomized trials of preoperative chemotherapy and radiation vs surgery alone

Ref.	Number of patients	Chemotherapy	Median survival (mo)		3-yr survival (%)
			+CRT	-CRT	+CRT	-CRT
Nygaard et al[14]1	103	CDDP/bleomycin	7	7	17	9
Le Prise et al[39]	86	CDDP/5-FU	11	11	19	14
Apinop et al[40]	69	CDDP/5-FU	9.7	7.4	26	20
Walsh et al[47]1	113	CDDP/5-FU	16	11	32	6
Bosset et al[38]	282	CDDP	18.6	18.6	39	37
Urba et al[46]	100	CDDP/vinblastine/5-FU	17.6	16.9	30	16
Burmeister et al[43]	257	CDDP/5-FU	22	19	-	-
Lee et al[48]	101	CDDP/5-FU	28.2	27.3	-	-
Tepper[45]1	56	CDDP/5-FU	53	21	-	-
van Hagen[41]1	386	Carbo/paclitaxel	49	24	58	44

¹The difference in survival was statistically significant. CDDP: Cisplatin; 5-FU: 5-flurouracil; CRT: Chemotherapy and radiation.