Multimodality approach for locally advanced esophageal cancer

Table 2 Randomized trials of preoperative chemotherapy vs surgery alone

Ref.	Number of patients	Chemotherapy	Median survival (mo)		3-yr survival (%)
			+CT	-CT	+CT	-CT
Roth JA et al[22]	39	CDDP/bleomycin/vindesin	> 201	8.6	-	-
Nygaard et al[14]	112	CDDP/bleomycin	7	7	3	9
Schlag[23]	46	CDDP/5-FU	7.5	5	-	-
Maipang et al[25]	46	CDDP/bleomycin	17	17	31	36
Law et al[24]	147	CDDP/5-FU	16.8	13	38	14
Kelsen et al[56]	440	CDDP/5-FU	14.9	16.1	42	45
MRC[26]	802	CDDP/5-FU	16.8	13.3	35	27
Ancona et al[28]1	94	CDDP/5-FU	25	24	44	41
Cunningham et al[27]1 503		ECF	-	-	79	50

¹The difference in survival was statistically significant. MRC: Medical Research Council Oesophageal Cancer Working Group; CDDP: Cisplatin; 5-FU: 5-flurouracil; ECF: Epirubicin, cisplatin and 5-fluorouracil; CT: Chemotherapy.