α-fetoprotein, vascular endothelial growth factor receptor-1 and early recurrence of hepatoma

Table 3 Clinical factors related to early hepatocellular carcinoma recurrence after curative hepatectomy

		Recurrence over 1 year (77)	Recurrence within 1 year (37)	P value
Sex	Male	64	30	0.7980
	Female	13	7
Age (yr)	≤ 60	30	23	0.0200
	> 60	47	14
HBsAg	+	24	25	0.0002
	-	53	12
HCV	+	34	12	0.2322
	-	43	25
Albumin	≤ 4.0 mg/dL	24	22	0.0039
	> 4.0 mg/dL	53	15
Total bilirubin	≤ 0.7 mg/dL	47	19	0.3266
	≥ 0.8 mg/dL	30	18
ICGR15	≤ 15%	43	18	0.4708
	> 15%	34	19
Anatomical resection	Yes	55	24	0.4769
	No	22	13
AFP	≤ 200 ng/mL	59	19	0.0066
	> 200 ng/nL	18	18
AFPL3	≤ 15%	58	21	0.0442
	> 15%	19	16
PIVKA-II	≤ 40 mAU/mL	32	6	0.0072
	> 40 mAU/mL	45	31
Tumor number	Solitary	62	20	0.0021
	Multiple	14	17
Tumor size	≤ 2 cm	36	6	0.0016
	> 2 cm	41	31
Differentiation	Well	7	0	0.1631
	Moderately	52	13
	Poorly	18	24
vp	Positive	11	16	< 0.0001
	Negative	66	21
vv	Positive	2	5	0.0230
	Negative	75	32
im	Positive	13	17	0.0010
	Negative	64	20
BM VEGFR1	Low	24	9	0.4506
	High	53	28
PH VEGFR1	Low	18	8
	High	54	24
BM AFP mRNA	Positive	17	17	0.0091
	Negative	60	20
PH AFP mRNA	Positive	2	4	0.0569
	Negative	74	31
BM-AFP mRNA/BM-VEGFR1	Negative/low	20	3	0.0228
	Negative/high	40	17
	Positive/low	4	6
	Positive/high	13	11

BM: Bone marrow; PH: Peripheral blood; AFP: α-fetoprotein; HBsAg: Hepatitis B surface antigen; VEGFR: Vascular endothelial growth factor receptor; HCV: Anti-hepatitis C virus antibody; ICGR15: Indocyanine green retention rate at 15 min; vp: Microscopic tumor thrombus in the portal vein; vv: Microscopic tumor thrombus in the hepatic vein; im: Microscopic intrahepatic metastasis.