α-fetoprotein, vascular endothelial growth factor receptor-1 and early recurrence of hepatoma

Table 2 Characteristics of hepatocellular carcinoma patients according to their bone marrow-vascular endothelial growth factor receptor-1 and peripheral blood-vascular endothelial growth factor receptor-1 mRNA profile

		BM-VEGFR1		P value	PH-VEGFR1		P value
		High (n = 81)	Low (n = 33)		High (n = 78)	Low (n = 26)
Sex	Male	67	27	0.9090	64	22	0.7647
	Female	14	6		14	4
Age (yr)	≤ 60	40	13	0.3322	37	12	0.9097
	> 60	41	20		41	14
HBsAg	+	35	14	0.9387	34	12	0.8197
	-	46	19		44	14
HCV	+	36	10	0.1628	32	9	0.5624
	-	45	23		46	17
Albumin	≤ 4.0 mg/dL	38	8	0.0252	27	12	0.2926
	> 4.0 mg/dL	43	25		51	14
Total bilirubin	≤ 0.7 mg/dL	48	18	0.6439	51	11	0.0378
	≥ 0.8 mg/dL	33	15		27	15
ICGR15	≤ 15%	41	20	0.3322	44	13	0.5695
	> 15%	40	13		34	13
Anatomical resection	Yes	55	24	0.6124	56	18	0.8026
	No	26	9		22	8
AFP	≤ 200 ng/mL	54	24	0.5278	57	16	0.2653
	> 200 ng/nL	27	9		21	10
AFPL3	≤ 15%	54	25	0.3399	59	15	0.0802
	> 15%	27	8		19	11
PIVKA-II	≤ 40 mAU/mL	24	14	0.1888	25	10	0.5491
	> 40 mAU/mL	57	19		53	16
Tumor number	Solitary	53	29	0.0068	55	18	0.8867
	Multiple	28	3		23	7
Tumor size	≤ 2 cm	9	3	0.7499	10	2	0.4784
	> 2 cm	72	30		68	24
Differentiation	Well	4	3	0.1151	6	1	0.1614
	Moderately	51	25		56	11
	Poorly	26	5		16	14
vp	Positive	26	6	0.1337	21	7	...
	Negative	55	27		57	19
vv	Positive	6	1	0.3773	4	1	0.7913
	Negative	75	32		74	25
im	Positive	23	7	0.4296	24	5	0.2559
	Negative	58	26		54	21
Noncancerous liver cirrhosis		34	5	0.0061	26	9	0.9962
Non liver cirrhosis		45	27		49	17

BM: Bone marrow; PH: Peripheral blood; AFP: α-fetoprotein; HBsAg: Hepatitis B surface antigen; VEGFR: Vascular endothelial growth factor receptor; HCV: Anti-hepatitis C virus antibody; AR: Patients who underwent anatomical resection; ICGR15: Indocyanine green retention rate at 15 min; vp: Microscopic tumor thrombus in the portal vein; vv: Microscopic tumor thrombus in the hepatic vein; im: Microscopic intrahepatic metastasis.