Biochemical characteristics of neonatal cholestasis induced by citrin deficiency

Table 1 Differential diagnosis have been excluded

Affecting bile duct	Infectious	Metabolic	Others
Biliary atresia	Herpes viruses	α-1 antitrypsin deficiency	Endocrinological
Choledochal cyst	Rubella virus	Neonatal iron storage disease	Hypothyroidism
Cholelithiasis	Enteroviruses	Amino acid disorders	Panhypopituitarism/septo-optic dysplasia
Inspissated bile	Hepatitis viruses	Tyrosinemia	Genetic
Tumor	Human immunodeficiency virus	Hypermethioninemia	ATP8B1 deficiency
Hemangioma	Syphilis	Mevalonate kinase dificiency	ABCB11 deficiency
Bile duct stenosis/stricture/perforation	Toxoplasmosis	Glucogen storage diseases	ABCB4 deficiency
Neonatal sclerosing cholangitis	Bacterial sepsis	Gaucher disease	Bile acid synthetic defects
Caroli disease	Urinary tract infections	Niemann–Pick disease	Neonatal Dubin–Johnson syndrome
Alagille syndrome		Wolman disease	Various trisomies
		Zellweger syndrome	Arghrogryposis
		Infantile Refsum disease	Hematological
		Mitochondrial disorders	Hemophagocytic lymphohistiocytosis
		Urea cycle disorders	Langerhans cell histiocytosis
			Miscellaneous drug effects
			Total parenteral nutrition