Identification of deregulated miRNAs and their targets in hepatitis B virus-associated hepatocellular carcinoma

Figure 1 MiRNA profiles differentiate hepatitis B virus-associated hepatocellular carcinoma from adjacent non-tumor tissues. A: The cluster analysis of down-regulated (green) and up-regulated (red) miRNAs identified in hepatocellular carcinoma (hepatitis B virus-hepatocellular carcinoma). Samples consist of paired samples from three patients; B: Validation of Taqman array data using quantitative reverse transcription polymerase chain reaction (RT-PCR) for up-regulated miRNA; C: Validation of Taqman array data using quantitative RT-PCR for down-regulated miRNA. Triplicate assays were done for each RNA sample and the relative amount of each miRNA was normalized to U6 snRNA. ^aP < 0.01 vs control group.