Axl glycosylation mediates tumor cell proliferation, invasion and lymphatic metastasis in murine hepatocellular carcinoma

Figure 4 Axl deglycosylation inhibits the ability of Hca-F cells to metastasize to peripheral lymph nodes in vivo. Untreated and treated Hca-F cells were injected into the footpads of 615-mice. After 3 wk’ inoculation, the mice were sacrificed and axillary lymph nodes isolated, weighed, measured, and photographed. A significant reduction in mean tumor weight (n = 6) of Axl tumor deglycosylation was observed, as compared with untreated Hca-F cells (^aP < 0.05 vs untreated Hca-F cells).