Myofibrillogenesis regulator-1 overexpression is associated with poor prognosis of gastric cancer patients

Table 2 Multivariate survival analysis of the prognosis factors by Cox regression analysis

Variables	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
MR-1 expression (positive vs negative)	2.502 (1.365-4.586)	0.003	2.125 (1.023-4.410)	0.043
TNM stage (stages III-IV vsI-II)	12.608 (3.845-41.345)	< 0.001	5.214 (1.155-23.526)	0.032
Depth of invasion (T3 + T4 vs T1 + T2)	7.094 (1.709-29.441)	0.007	3.340 (0.612-18.212)	0.164
Distant metastasis (M1 vs M0)	0.395 (0.166-0.943)	0.036	0.579 (0.199-1.686)	0.316
Gender (male vs female)	1.180 (0.635-2.192)	0.601	0.783 (0.376-1.631)	0.514
Age (yr) (< 55 vs≥ 55)	0.603 (0.324-1.122)	0.110	0.717 (0.340-1.514)	0.383
Location (upper vs lower)	1.740 (0.726-4.168)	0.214	1.136 (0.449-2.876)	0.787
Vascular invasion (positive vs negative)	0.517 (0.267-1.001)	0.046	0.964 (0.456-2.038)	0.924
Lymph node metastasis (positive vs negative)	4.973 (1.529-16.176)	0.008	1.158 (0.249-5.382)	0.852
Differentiation (well differentiated vs poorly differentiated)	0.774 (0.478-1.254)	0.298	0.831 (0.485-1.426)	0.502

HR: Hazard ratio; CI: Confidence interval; TNM: Tumor node metastasis; MR-1: Myofibrillogenesis regulator-1.