Coexistence of hyperlipidemia and acute cerebral ischemia/reperfusion induces severe liver damage in a rat model

Figure 1 Histology and in situ apoptosis of liver sections from rats after high-fat diet treatment for 18 wk and/or 2 h transient focal cerebral ischemia followed by 24 h reperfusion. A: HE staining showed liver damage in the hyperlipemia (HL) group and especially in the HL+ ischemia/reperfusion (I/R) group (× 200); B: Transferase dUTP nick-end labeling (TUNEL) staining showed TUNEL-positive apoptotic hepatocytes in the HL+I/R group are significantly greater than those in control, HL or I/R groups (× 200). Slides are representative of 6-10 animals per group.