Does gemcitabine-based combination therapy improve the prognosis of unresectable pancreatic cancer?

Table 2 Grade 3 or 4 toxicity of selected clinical trials

Ref.	Intervention	Vomiting	Diarrhea	Neutropenia	Anemia	Thrombocytopenia
Louvet et al[15]	Gem	3.2	1.3	27.6	10.3	3.2
	Gem + Oxaliplatin	8.9	5.7	20.4	6.4	14.0
Poplin et al[16]	Gem	7	4	33	10	13
	Gem + Oxaliplatin	16	6	22	6	11
Heinemann et al[17]	Gem	5.9	4.7	NR	10.6	10.6
	Gem + Cisplatin	22.2	3.3	NR	13.3	4.4
Colucci et al[18]	Gem	2	0	9	4	2
	Gem + Cisplatin	2	4	18	6	2
Colucci et al[19]	Gem	< 1	1.5	13.7	1	18.9
	Gem + Cisplatin	2.6	< 1	24.7	4.8	15.3
Kulke et al[20]	Gem	24.1	NR	82.8	20	43.1
	Gem + Cisplatin	29	NR	74.2	25.8	79
	Gem + Irinotecan	16.7	NR	41.7	8.3	23.3
Berlin et al[21]	Gem	8	NR	5	10	11
	Gem + 5-fluorouracil	7	NR	7	10	19
Herrmann et al[22,24]	Gem	4	2	19	6	8
	Gem + Capeitabine	4	5	23	8	4
Cunningham et al[23]	Gem	6	4	22	6	6
	Gem + Capeitabine	6	5	35	4	11
Scheithauer et al[25]	Gem	0	0	7.6	0	2.5
	Gem + Capeitabine	0	5	10	5	0
Costanzo et al[26]	Gem	0	0	2	6	0
	Gem + 5-fluorouracil	2	0	2	7	2
Abou-Alfa et al[27]	Gem	3.1	< 1	14.6	7.6	4.4
	Gem + Exatecan	5.3	1.1	30.3	5.9	15.4
Stathopoulos et al[28]	Gem	1.4	2.8	15.7	4.2	0
	Gem + Irinotecan	1.6	3.2	26.6	5	5
Lima et al[29]	Gem	8.2	1.8	31.9	13	14.2
	Gem + Irinotecan	13.9	18.5	37.6	16.2	19.6
Moore et al[38]	Gem	NR	< 1	27%	NR	11%
	Gem + Erlotinib	NR	2	24%	NR	10%
Cutsem et al[39]	Gem	9	3	30	16	12
	Gem + Tipifarnib	7	4	40	20	15
Eckhardt et al[40]	Gem	9.3	0	33.9	11	15.3
	Gem + Tipifarnib	4	0	35.5	12.1	16.1
Philip et al[37]	Gem	2.2	2.5	23.9	6.2	8.5
	Gem + cetuximab	6.6	2.8	23.3	9.7	6.6
Kindler et al[36]	Gem	NR	NR	29	8	12
	Gem + Bevacizumab	NR	NR	33	5	12
Kindler et al[35]	Gem	3.2	1.6	< 1	< 1	< 1
	Gem + Axitinib	3.9	1.3	0	0	0
Spano et al[41]	Gem	10	0	33	17	13
	Gem + Axitinib	6	6	28	8	20
Richards et al[33]	Gem	0	2.6	28.2	5.1	25.6
	Gem + Enzastarin	2.4	3.7	18.3	3.7	14.6
Bramhall et al[31]	Gem	14%	NR	NR	7%	NR
	Gem + Marimastat	6%	NR	NR	3%	NR
Richards et al[32]	Gem	9	3	NR	5	11
	Gem + CA-994	9	5	NR	13	2
Oettle et al[30]	Gem	3.7	0.7	12.8	2.9	6.2
	Gem + Pemetrexed	3.3	2.9	45.1	13.9	17.9

NR: No record.