Coexistence of hyperlipidemia and acute cerebral ischemia/reperfusion induces severe liver damage in a rat model

Table 4 Levels of antioxidant enzymes, malondialdehyde and Ca²⁺ in liver mitochondria of different groups after high-fat diet treatment for 18 wk and/or 2 h transient focal cerebral ischemia followed by 24 h reperfusion (mean ± SD)

Group	n	SOD (U/μg protein)	GSH-Px (nmol/g protein per min)	MDA (mmol/g protein)	Ca2+ (μmol/g protein)
Control	10	244.93 ± 33.70	2172.26 ± 241.34	7.02 ± 2.58	1.329 ± 0.279
HL	6	100.59 ± 40.72b	937.57 ± 228.68b	21.84 ± 6.01b	2.552 ± 0.317b
I/R	7	172.15 ± 57.31a	1762.65 ± 409.18	12.58 ± 5.34	2.180 ± 0.431b
HL+I/R	6	59.01 ± 21.48bcf	486.41 ± 230.52bdf	47.27 ± 7.11bcf	3.136 ± 0.517bcf

HL: Hyperlipidemia; I/R: Ischemia/reperfusion; SOD: Superoxide dismutase; GSH-Px: Glutathione peroxidase; MDA: Malondialdehyde.

^aP < 0.05,

^bP < 0.01 vs control group;

^cP < 0.05,

^dP < 0.01 vs HL group;

^fP < 0.01 vs I/R group.