Coexistence of hyperlipidemia and acute cerebral ischemia/reperfusion induces severe liver damage in a rat model

doi:10.3748/wjg.v18.i35.4934

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 21, 2012; 18(35): 4934-4943
Published online Sep 21, 2012. doi: 10.3748/wjg.v18.i35.4934

Table 3 Brain infarct volume and serum alanine aminotransferase and aspartate aminotransferase in different groups after high-fat diet treatment for 18 wk and/or 2 h transient focal cerebral ischemia followed by 24 h reperfusion (mean ± SD)

Group	n	Neurological deficit score	Infarct volume (mm³)	ALT (U)	AST (U)
Control	10	0	0	9.56 ± 1.99	11.33 ± 4.17
HL	6	0	0	25.13 ± 16.90^b	18.01 ± 10.00^a
I/R	7	3.25 ± 0.36^b^d	33.4 ± 4.16^b^d	12.93 ± 6.14	14.00 ± 6.19
HL+I/R	6	3.53 ± 0.45^b^d	34.5 ± 6.23^b^d	93.62 ± 24.00^b^d^f	82.32 ± 26.92^b^d^f

HL: Hyperlipidemia; I/R: Ischemia/reperfusion; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.

^aP < 0.05,

^bP < 0.01 vs control group;

^dP < 0.01 vs HL group;

^fP < 0.01 vs I/R group.

Citation: Gong WH, Zheng WX, Wang J, Chen SH, Pang B, Hu XM, Cao XL. Coexistence of hyperlipidemia and acute cerebral ischemia/reperfusion induces severe liver damage in a rat model. World J Gastroenterol 2012; 18(35): 4934-4943
URL: https://www.wjgnet.com/1007-9327/full/v18/i35/4934.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i35.4934