Prognosis of hepatocellular carcinoma expressing cytokeratin 19: Comparison with other liver cancers

Figure 2 Clinical outcome after the curative liver resection of primary liver cancers. A: Overall survival (OS) rates of different groups of primary liver cancer after the curative resection. The OS rates of cytokeratin 19 positive hepatocellular carcinoma (CK19⁺ HCC) and combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) were significantly lower than that of cytokeratin 19 negative hepatocellular carcinoma (CK19^- HCC), but higher than the OS rate of intrahepatic cholangiocarcinoma (ICC) (P < 0.05). There was no statistically significant difference in OS rate between CK19⁺ HCC and cHCC-CC (P = 0.245); B: Disease free survival (DFS) rate. The DFS rate of CK19^- HCC was significantly higher than that of ICC (P = 0.017), but marginally higher than DFS rate of either CK19⁺ HCC or cHCC-CC (P = 0.097, 0.089, respectively).