Prognosis of hepatocellular carcinoma expressing cytokeratin 19: Comparison with other liver cancers

Table 2 Univariate and multivariate analysis of predictors of survival

	Univariate analysis	Multivariate analysis
Variable	P value	Hazard ratio	95% CI	P value
Pathologc diagnosis	0.000			0.000
CK19- HCC
CK19+ HCC		3.055	1.235-7.558	0.016
cHCC-CC		4.588	1.953-10.781	0.000
ICC		6.986	2.997-16.284	0.000
Age (yr)	0.672
< 45 vs≥ 45
Gender	0.197
Cirrhosis	0.542
Tumor size (cm)	0.000
< 5 vs≥ 5
Tumor number	0.179
Single vs multiple
Satellite nodule	0.001	1.997	1.010-3.949	0.047
Microvascular invasion	0.005	2.884	1.491-5.581	0.002
Macrovascular invasion	0.000
Lymph node metastasis	0.002
Distant metastasis	0.111

CK19^- HCC: Cytokeratin 19 negative hepatocellular carcinoma; CK19⁺ HCC: Cytokeratin 19 positive hepatocellular carcinoma; cHCC-CC: Combined hepatocellular carcinoma and cholangiocarcinoma; ICC: Intrahepatic cholangiocarcinoma; 95% CI: 95% confidence interval.