Primary biliary cirrhosis-specific autoantibodies in first degree relatives of Greek primary biliary cirrhosis patients

Table 2 Surgical history and comorbidities in first degree relatives of patients with autoimmune liver diseases and healthy controls n (%)

	PBC FDRs (n = 101)	AIH-1 and PSC FDRs (n = 40)	Healthy (n = 40)
History of comorbidities
Sjögren’s syndrome	7 (6.9)	1 (2.5)	0
Raynaud’s syndrome	8 (7.9)	2 (5)	0
Autoimmune thyroiditis	4 (3)	0	0
Rheumatoid arthritis	1 (1)	0	0
Systemic lupus erythematosous	0	1 (1)	0
Asthma	3 (3)	4 (10)	0
Atopic dermatitis	2 (2)	1 (2.5)	0
Vitiligo	1 (1)	0	0
Psoriasis vulgaris	1 (1)	0	0
Erythema nodosum	1 (1)	0	0
Type 1 diabetes mellitus	1 (1)	1 (2.5)	0
Idiopathic thrombocytopenic purpura	1 (1)	0	0
Osteoporosis	4 (4)	3 (7.5)	0
Urinary tract infections	33 (32.7)a	11 (27.5)	6 (15)
Hypercholesterolemia	10 (9.9)	7 (17.5)	4 (10)
Hypertension	6 (5.9)	5 (12.5)	3 (7.5)
History of surgery
Tonsillectomy	14 (13.9)	3 (7.5)	3 (7.5)
Appendectomy	18 (17.8)	7 (17.5)	5 (12.5)
Cholecystectomy	6 (5.9)	1 (2.5)	1 (2.5)
Inguinal hernia	14 (13.9)bc	0	1 (2.5)

^aP < 0.05 vs healthy controls;

^bP = 0.01 vs autoimmune hepatitis-1 (AIH-1)/primary sclerosing cholangitis (PSC) first-degree relatives (FDRs);

^cP = 0.05 vs healthy controls. PBC: Primary biliary cirrhosis.