Characteristics of intestinal pseudo-obstruction in patients with mitochondrial diseases

Table 2 Age at the oncet of mitochondrial disease and chronic intestinal pseudo-obstruction

Sex	Subclass	Age at the onset of mitochondrial disease, yr	Age at the diagnosis of mitochondrial disease, yr	Age at the diagnosis of CIP, yr
F	MELAS	Difficulty in walking at 40	40	40
M	MELAS	Glucose intolerance at 13	57	46
M	MERRF	Difficulty in walking at 41	50	50
F	CPEO	Palpebral ptosis at 71	81	-
F	MELAS	Impaired hearing at 45	54	-
M	MELAS	Impaired hearing at 24	29	-
M	CPEO	Palpebral ptosis at 40	69	-
F	CPEO	Impaired eye movement at 30	52	-
F	MELAS	Impaired hearing at 25	40	43
M	CPEO	Palpebral ptosis at 49	49	-
F	MERRF	Muscular weakness at 46	54	-
M	MELAS	Impaired hearing at 47	52	-
M	MELAS	Epilepsy at 11	18	-
M	CPEO	Glucose intolerance at 40	67	-
M	MELAS	Impaired hearing at 24	31	-
F	MELAS	Impaired hearing at 12	17	25
F	MELAS	Impaired hearing at 54	60	-
F	MELAS	Epilepsy at 40	44	-
M	MELAS	Glucose intolerance and impaired hearing at 18	18	-
F	MELAS	-	23	-
F	MELAS	Chronic diarrhea at 26	40	-1
F	MELAS	Epilepsy at 18	18	26
F	MELAS	Difficulty in walking and hearing at 63	69	69
F	MELAS	Glucose intolerance at 33	42	55
M	CPEO	Palpebral ptosis at 16	44	-
M	MELAS	Epilepsy at 29	29	-
F	CPEO	Palpebral ptosis at 13	17	-
F	CPEO	Palpebral ptosis at 59	59	-
M	MELAS	Epilepsy at 21	21	34
F	MELAS	Glucose intolerance at 46	48	-
F	MERRF	Difficulty in walking at 20	50	-

¹This patient died of uncontrolled epilepsy and aspiration pneumonia 5 mo after the onset of intestinal pseudo-obstruction and did not fulfill the diagnostic criteria. M: Male; F: Female; CIP: Chronic intestinal pseudo-obstruction; MERRF: Myoclonus epilepsy associated with ragged-red fibers; MELAS: Mitochondrial encephalopathy with lactic acidosis and stroke-like episodes; CPEO: Chronic progressive external ophthalmoplegia.