Diabetes but not insulin is associated with higher colon cancer mortality

Table 4 Cox proportional hazards models for mortality from colon cancer by duration of insulin use (reference group: diabetic patients not using insulin) before and after exclusion of patients with a duration of < 5 years between onset of diabetes and colon cancer mortality

	Duration of insulin use
Variables adjusted	<5 yr			5-9 yr			≥10 yr
	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value
Before exclusion
Unadjusted	1.128	0.734-1.735	0.5824	1.245	0.664-2.333	0.4947	1.539	0.918-2.579	0.1018
Age	1.388	0.902-2.136	0.1355	1.487	0.793-2.787	0.2163	1.441	0.860-2.416	0.1654
Sex	1.146	0.745-1.763	0.5339	1.267	0.676-2.375	0.4605	1.562	0.932-2.618	0.0907
Diabetes type	1.101	0.682-1.777	0.6931	0.817	0.362-1.843	0.6259	1.321	0.589-2.964	0.4991
Diabetes duration	1.009	0.655-1.556	0.9663	1.028	0.546-1.935	0.9330	1.018	0.590-1.756	0.9491
Body mass index	1.089	0.707-1.675	0.6995	1.210	0.645-2.268	0.5530	1.505	0.898-2.523	0.1208
Smoking	1.143	0.743-1.759	0.5416	1.263	0.674-2.367	0.4666	1.549	0.924-2.596	0.0966
Area of residence	1.122	0.729-1.726	0.6005	1.237	0.660-2.318	0.5074	1.538	0.918-2.578	0.1023
Full model1	1.217	0.764-1.937	0.4082	0.943	0.442-2.010	0.8788	1.003	0.454-2.212	0.9948
After exclusion
Unadjusted	1.108	0.698-1.761	0.6630	1.416	0.755-2.656	0.2782	1.746	1.041-2.931	0.0348
Age	1.384	0.871-2.199	0.1696	1.704	0.908-3.197	0.0971	1.633	0.973-2.740	0.0635
Sex	1.129	0.710-1.793	0.6085	1.445	0.771-2.711	0.2510	1.776	1.058-2.981	0.0297
Diabetes type	1.089	0.651-1.821	0.7447	1.010	0.446-2.287	0.9807	1.700	0.770-3.757	0.1893
Diabetes duration	0.943	0.592-1.501	0.8045	1.079	0.573-2.034	0.8133	0.968	0.561-1.669	0.9057
Body mass index	1.072	0.674-1.703	0.7702	1.375	0.733-2.581	0.3215	1.710	1.019-2.870	0.0424
Smoking	1.126	0.708-1.788	0.6164	1.440	0.768-2.701	0.2557	1.760	1.049-2.954	0.0323
Area of residence	1.103	0.694-1.752	0.6786	1.409	0.751-2.643	0.2855	1.746	1.040-2.929	0.0349
Full model1	1.133	0.691-1.857	0.6214	1.038	0.491-2.195	0.9221	1.003	0.462-2.178	0.9949

¹Adjusted for age, sex, diabetes type, diabetes duration, body mass index, smoking and area of residence. HR: Hazard ratio; CI: Confidence interval.