Human papilloma virus 16 E6 oncoprotein associated with p53 inactivation in colorectal cancer

Table 2 p53 mutation, p53 protein, E6 oncoprotein and clinical information in human papilloma virus 16 DNA-positive colorectal patients

PatientNo.	Gender	Age(yr)	Stage	Site	p53		HPV16
					Mutation	IHC	ISH	E6
101	F	65	I	d-colon	No	-	+	+
134	F	54	IIA	Rectum	No	+	+	+
141	M	72	I	Rectum	No	-	+	+
142	F	56	IIA	d-colon	Yes	++	+	+
167	M	70	IIIB	d-colon	Yes	+++	+	+
169	M	78	IV	Rectum	No	-	+	+
173	F	83	IIA	s-colon	Yes	+	+	+
200	M	74	IV	a-colon	Yes	+	+	+
226	F	78	I	Rectum	No	-	-	-
234	F	76	I	a-colon	No	+	-	-
259	F	79	IIIB	Rectum	Yes	++	-	-

HPV: Human papilloma virus; IHC: Immunohistochemistry; ISH: In situ hybridization. -: No positive staining; +: 1%-10%; ++: 1%-50%; +++: > 50% positive cells.