1H NMR-based serum metabolic profiling in compensated and decompensated cirrhosis

Figure 1 600 MHz 1H NMR spectra (δ0. 5-4.7 and δ5.2-9.0) of serum obtained from (C) control, (B) compensated liver cirrhosis and (A) decompensated liver cirrhosis patients. The region of δ5.2-9.0 (in the dashed box) is magnified 8 times compared to the corresponding region of δ0.5-4.7 for the purpose of clarity. 3-HB: 3-Hydroxybutyrate; Ace: Acetate; Acet: Acetone; Ala: Alanine; Cit: Citrate; Cr: Creatine; FD: Formaldehyde; Glu: Glutamate; Gln: Glutamine; Gly: Glycine; GPC: Glycerophosphocholine; His: Histidine; Ile: Isoleucine; IB: Isobutyrate; Lac: Lactate; Leu: Leucine; L1 Lipid: CH₃-(CH₂)n-(LDL&VLDL); L2 Lipid: CH₃-(CH₂)n-(LDL&VLDL); L3 Lipid: -CH₂-CH₂-C=O; L4 Lipid: -CH₂-CH=CH-; L5 Lipid: =CH-CH₂-CH=; L6 Lipid: -CH=CH-; Lys: Lysine; NAG: N-acetyl glycoprotein signals; PC: Phosphocholine; Phe: Phenylalanine; Py: Pyruvate; Suc: Succinate; TMA: Trimethylamine; Tyr: Tyrosine; Val: Valine; α-Glc: α-Glucose; β-Glc: β-Glucose.