Alanine and aspartate aminotransferase and glutamine-cycling pathway: Their roles in pathogenesis of metabolic syndrome

Table 3 Gene ontology annotation of predicted biological process

Gene ontology annotation	Q value	Genes in network	Genes in genome
Transaminase activity	4.86E-31	14	16
Transferase activity, transferring nitrogenous groups	6.17E-30	14	18
Mitochondrial matrix	3.10E-15	16	220
Cellular amino acid catabolic process	7.40E-15	12	77
Amine catabolic process	1.13E-14	12	81
Dicarboxylic acid metabolic process	1.75E-14	9	24
Cellular amino acid biosynthetic process	5.90E-13	10	54
Carboxylic acid catabolic process	2.55E-12	12	131
2-oxoglutarate metabolic process	2.55E-12	7	13
Organic acid catabolic process	2.55E-12	12	131
Amine biosynthetic process	8.11E-12	10	72
Glutamate metabolic process	1.08E-10	6	10
Carboxylic acid biosynthetic process	4.53E-10	11	154
Organic acid biosynthetic process	4.53E-10	11	154
Small molecule catabolic process	4.87E-10	12	211
Small molecule biosynthetic process	2.21E-9	12	241
Cofactor metabolic process	2.24E-8	10	163
Vitamin B6 binding	9.53E-8	5	12
Glutamine family amino acid metabolic process	9.53E-8	6	27
Cellular aromatic compound metabolic process	9.53E-8	9	135
Pyridoxal phosphate binding	9.53E-8	5	12
Cofactor binding	6.48E-7	7	69
Aromatic amino acid family catabolic process	1.24E-6	5	19
Coenzyme metabolic process	1.46E-6	8	126
Aromatic compound catabolic process	3.14E-6	5	23
Aromatic amino acid family metabolic process	3.14E-6	5	23
Vitamin binding	8.74E-6	5	28
Indolalkylamine catabolic process	1.08E-5	4	11
Indole-containing compound catabolic process	1.08E-5	4	11
Tryptophan catabolic process	1.08E-5	4	11
Tryptophan metabolic process	1.48E-5	4	12
Indolalkylamine metabolic process	1.48E-5	4	12
Indole-containing compound metabolic process	1.48E-5	4	12
Cellular biogenic amine catabolic process	3.93E-5	4	15
Serine family amino acid metabolic process	5.07E-5	4	16
Acetyl-CoA catabolic process	1.23E-4	4	20
Tricarboxylic acid cycle	1.23E-4	4	20
Coenzyme catabolic process	1.23E-4	4	20
Cofactor catabolic process	3.67E-4	4	26
Aerobic respiration	4.88E-4	4	28
Cellular biogenic amine metabolic process	6.98E-4	5	71
Lyase activity	8.37E-4	5	74
Acetyl-CoA metabolic process	1.01E-3	4	34
Transferase activity, transferring acyl groups other than amino-acyl groups	1.41E-3	5	83
Gluconeogenesis	3.05E-3	4	45
Aspartate family amino acid catabolic process	3.67E-3	3	15
Generation of a signal involved in cell-cell signaling	3.67E-3	6	178
Signal release	3.67E-3	6	178
Transferase activity, transferring acyl groups	3.67E-3	5	103
Sulfur amino acid metabolic process	4.26E-3	3	16
Neurotransmitter secretion	5.20E-3	4	53
Hexose biosynthetic process	5.50E-3	4	54
Water-soluble vitamin metabolic process	6.24E-3	4	56
Monosaccharide biosynthetic process	1.04E-2	4	64
Pteridine-containing compound metabolic process	1.05E-2	3	22
Neurotransmitter transport	1.14E-2	4	66
Carbon-carbon lyase activity	1.48E-2	3	25
Aspartate family amino acid metabolic process	1.48E-2	3	25
Regulation of neurotransmitter levels	1.60E-2	4	73
Sphingolipid metabolic process	1.82E-2	4	76
Alcohol biosynthetic process	1.82E-2	4	76
Pigment biosynthetic process	1.96E-2	3	28
Membrane lipid metabolic process	2.35E-2	4	82
Sphingolipid biosynthetic process	2.35E-2	3	30
Cofactor biosynthetic process	2.53E-2	4	84
Membrane lipid biosynthetic process	2.77E-2	3	32
Cellular modified amino acid metabolic process	2.81E-2	4	87
Cellular carbohydrate biosynthetic process	4.06E-2	4	96
Pigment metabolic process	4.80E-2	3	39
Vitamin metabolic process	4.80E-2	4	101

Q value stands for the P value corrected for multiple testing. In addition, number of genes in the network and in the whole genome belonging to the biological process is depicted. The candidate genes are listed in Table 2, which are involved in functional enrichment analysis using the GeneMANIA tool (genemania.org).