Uncoupling protein 2 regulates glucagon-like peptide-1 secretion in L-cells

Figure 2 Glucagon-like peptide-1 secretion in NCI-H716 cells after treatment with oleic acid. A: Time course of oleic acid-induced release of glucagon-like peptide-1 (GLP-1) from NCI-H716 cells. NCI-H716 cells were incubated with 8 mmol oleic acid, and the culture medium was collected at 0.25, 0.5, 1, 2, and 3 h to detect GLP-1 levels; B: Dose-dependent oleic acid-induced release of GLP-1 from NCI-H716 cells. NCI-H716 cells were incubated with 2, 4, 6, 8, and 10 mmol oleic acid for 2 h. The culture medium was then analyzed for GLP-1 concentration. NCI-H716 cells without oleic acid exposure. ^aP < 0.05, ^bP < 0.01 vs baseline value.