Preoperative predictors of short-term survival after hepatectomy for multinodular hepatocellular carcinoma

Table 2 Univariate Cox analysis of potential prognostic factors

Variables	n	The 1-year survival rates %	P value
Age			< 0.001
> 40 yr	128	85.9
≤ 40 yr	34	64.7
Parameters of liver function
TBIL			< 0.001
> 17.1 μmol/L	49	58.33
≤ 17.1 μmol/L	113	91.22
ALB			0.530
< 35 g/L	8	75.00
≥ 35 g/L	154	81.82
GLB			0.565
> 30 g/L	79	79.48
≤ 30 g/L	83	83.33
Prealbumin			< 0.001
< 170 mg/L	33	58.3
≥170 mg/L	129	90.6
ALT			0.281
> 38 U/L	82	78.04
≤ 38 U/L	80	85.00
ALT			0.993
> 76 U/L	10	80.00
≤ 76 U/L	152	81.58
AST			0.001
> 38 U/L	88	75.00
≤ 38 U/L	74	89.21
AFU			0.004
> 40 U/L	31	64.31
≤ 40 U/L	131	85.89
ALP			0.001
> 129 U/L	27	58.33
≤ 129 U/L	135	85.50
GGT			< 0.001
> 64 U/L	82	65.00
≤ 64 U/L	80	97.56
PT			0.428
> 13 s	41	75.00
≤ 13 s	121	82.00
APTT			0.566
> 37 s	72	77.80
≤ 37 s	90	82.20
Parameters of blood test
WBC			0.389
< 4 × 109/L	35	76.5
≥ 4 × 109/L	127	82.5
PLT			< 0.001
< 100 × 109/L	44	59.1
≥100 × 109/L	118	89.7
Parameters of tumors
Total tumor size			0.010
> 5 cm	108	75.9
≤ 5 cm	54	92.6
Total tumor size			< 0.001
> 8 cm	54	66.7
≤ 8 cm	108	88.9
Largest tumor size			0.050
> 5 cm	58	72.41
≤ 5 cm	104	84.61
Largest tumor size			0.001
> 8 cm	22	54.54
≤ 8 cm	140	84.2
AFP			< 0.001
> 20 μg/L	102	72.00
≤ 20 μg/L	60	96.78
AFP			0.014
> 400 μg/L	59	72.41
≤ 400 μg/L	103	86.54
CA19-9			0.287
> 39 U/L	35	72.22
≤ 39 U/L	127	83.87
Location in same segment
Yes	20	80.00	0.924
No	142	81.96
Location in same lobe
Yes	34	88.2	0.238
No	128	79.7
Location in same hemiliver
Yes	74	83.8	0.530
No	88	79.5
Number of tumors			0.529
≤ 3	146	80.82
> 3	16	87.50
Parameters of hepatitis B
HBsAg			0.517
Positive	156	80.81
Negative	6	100.00
HBsAb			0.803
Positive	8	100.0
Negative	154	80.52
HBeAg
Positive	64	71.88	0.005
Negative	98	87.76
HBeAb
Positive	101	84.31	0.041
Negative	61	74.19
HBV-DNA1			0.228
> 104/L	88	79.54
≤ 104/L	50	88.00
HBV-DNA1			0.019
> 106/L	32	68.75
≤ 106/L	106	86.79

¹There were only 138 patients received HBV-DNA examinations. GLB: Globulin; ALP: Alkaline phosphatase; AFU: α fucosidase; GGT: γ-glutamyl transpeptidase; PLT: Platelet; HBV: Hepatitis B virus; HBsAg: Hepatitis B surface antigen; HBeAg: Hepatitis B e antigen; HBsAb: Hepatitis B surface antibody; HBeAb: Hepatitis B e antibody; CA19-9: Carbohydrate antigen 19-9; PT: Prothrombin time; APTT: Activated partial thromboplastin time; TBIL: Total bilirubin; ALB: Albumin; ALT: Alanine transaminase; AST: Aspartate aminotransferase; WBC: White blood cell.