Gastric mucosal damage in water immersion stress: Mechanism and prevention with GHRP-6

Figure 1 Gross anatomy of rat gastric mucosa in different groups. Left three columns: The gross inspections of the gastric mucosa in water immersion restraint stress (WRS), WRS + growth hormone releasing peptide-6 (GHRP-6) and simple restraint (SR) groups, respectively. Note that there were serious mucosal hemorrhages (black color) in the WRS group, while the hemorrhage was minimal in the WRS + GHRP-6 group. No mucosal hemorrhage was observed in the SR group; the forth column: Hematoxylin-eosin staining of the mucosa, mucosal structure disruption and hemorrhage (brown color) were observed in the WRS group, but not in the WRS + GHRP-6 and SR groups.