Knockdown of liver-intestine cadherin decreases BGC823 cell invasiveness and metastasis in vivo

doi:10.3748/wjg.v18.i24.3129

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Jun 28, 2012 (publication date) through Apr 19, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 28, 2012; 18(24): 3129-3137
Published online Jun 28, 2012. doi: 10.3748/wjg.v18.i24.3129

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Figure 2 Tumors in which liver-intestine cadherin was knocked down show fewer invasive characteristics in vivo. Hematoxylin-eosin staining revealed that primary orthotopic tumors (A, B) derived from BGC823 or lenti-liver-intestine cadherin (CDH17)-miR-neg cells spread into the liver (C, D) and lung (E, F) more frequently than those derived from lenti-CDH17-miR-B cells. Nude mice injected with these two types of tumors also showed invasion of the diaphragmatic muscle (G) and spleen (H).

Citation: Xu Y, Zhang J, Liu QS, Dong WG. Knockdown of liver-intestine cadherin decreases BGC823 cell invasiveness and metastasis in vivo. World J Gastroenterol 2012; 18(24): 3129-3137
URL: https://www.wjgnet.com/1007-9327/full/v18/i24/3129.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i24.3129