Intervention of Mirtazapine on gemcitabine-induced mild cachexia in nude mice with pancreatic carcinoma xenografts

Table 1 Effect of Mirtazapine on body weight and nutritional status

Nutritional status	Group	Baseline	5 d	9 d	13 d	17 d	21 d	25 d	28 d
Body weight (g)	Control	21.64 ± 0.96	21.51 ± 0.89	21.20 ± 0.73	20.86 ± 0.71	20.15 ± 0.67	18.70 ± 0.58	17.24 ± 0.53	16.04 ± 0.66
	Mirtazapine	21.75 ± 0.75	21.69 ± 0.79	21.59 ± 0.75	21.14 ± 0.52	20.50 ± 0.50	19.13 ± 0.55	18.05 ± 0.68	16.89 ± 0.73
	P value	0.783	0.654	0.282	0.386	0.266	0.151	0.014	0.017
Subcutaneous fat (mm)	Control	0.74 ± 0.14	0.72 ± 0.14	0.70 ± 0.13	0.69 ± 0.09	0.66 ± 0.09	0.60 ± 0.10	0.50 ± 0.10	0.41 ± 0.07
	Mirtazapine	0.71 ± 0.12	0.70 ± 0.11	0.70 ± 0.10	0.69 ± 0.10	0.68 ± 0.10	0.63 ± 0.10	0.52 ± 0.09	0.44 ± 0.08
	P value	0.691	0.773	0.928	0.938	0.845	0.697	0.708	0.548
Arm circumference (mm)	Control	19.45 ± 1.21	19.03 ± 0.81	18.29 ± 0.88	17.24 ± 0.52	16.00 ± 0.62	15.13 ± 0.68	13.76 ± 0.65	13.06 ± 0.52
	Mirtazapine	19.52 ± 0.88	19.20 ± 0.73	18.51 ± 0.65	17.58 ± 0.67	16.27 ± 0.67	15.31 ± 0.68	14.04 ± 0.54	13.25 ± 0.53
	P value	0.901	0.694	0.619	0.323	0.482	0.621	0.424	0.566